Serbian world number two Djokovic made it six straight wins over Frenchman Julien Benneteau with a resounding 6-1 6-3 victory in their quarter-final clash at Indian Wells.
Djokovic took just 68 minutes to progress and lost only eight points when serving on the hard courts at the ATP 1000 event.
The 2008 and 2011 champion rushed through the first set in 28 minutes, breaking twice to put Benneteau on the back foot.
Benneteau saved seven break points early in the second set but double-faulted on the eighth in the seventh game to hand Djokovic a 4-3 lead.
The six-time grand slam winner broke again in the ninth game to continue his strong record over Benneteau, who won the first meeting between the pair in 2006.
In what will be a repeat of their 2012 semi-final, Djokovic faces American Isner in the last four.
The 12th seed battled to a 7-6 (7-4) 7-6 (7-3) victory over Latvian 20th seed Ernests Gulbis in the day's other quarter-final.
Isner served 13 aces and recovered from a break down in the second set to reach the semi-finals at Indian Wells for just the second time.
Djokovic said he was ready for three tight sets against the big-serving American.
"I played John here a few years ago and I remember that match. (Isner won) 7-6 in the third, and I also lost to him in a very close one in Cincinnati last year," he said.
"He's definitely not somebody you like to play in the big heat with such serve. It's very challenging because he doesn't miss his serve too much.
"You have to kind of be able to hold your composure from the first to the last point and be ready to play three tie-breaks."
Novak Djokovic through to last four at Indian Wells
