With John Isner bowing out at the hands of Feliciano Lopez on Friday, it meant for the first time in the Australian Open history no American male made it to the last 16 at Melbourne Park.
While the United States no longer boast class players of the ilk of past champions Arthur Ashe, Jimmy Connors, Andre Agassi, Pete Sampras and Jim Courier, they did come to Melbourne in 2012 boasting three male players currently ranked in the top 20 in the world.
Andy Roddick may have been hampered by injury in his loss to Australia's Lleyton Hewitt, but what happened to No.8 seed Mardy Fish and fellow top 20 player Isner?
Fish got knocked out in straight sets by Colombian Alejandro Falla in the second round, later complaining his opponent had cynically taken medical timeouts for little more than cramp, while Isner fell in yet another five-set match against Lopez.
The other American ranked in the top 50, Donald Young, didn't fare much better as he lost in the second round to Lukas Lacko, while Ryan Sweeting, Ryan Harrison, Sam Querrey and Michael Russell also made early exits at the year's first Slam.
Roddick was the last American to hoist a major trophy, way back in 2003 at the US Open, and since then there has hardly been an influx of quality players coming through the ranks.
That's left Roddick to fly the flag in a period in which he has lost a pair of Wimbledon finals and also another Flushing Meadows decider, all against Roger Federer.
So what is wrong with the young breed of American men these days?
Isner was quizzed on the subject following his match with Lopez and the pain and anguish on his face when answering gave the impression that the big-serving American felt he had let his country down.
"It's very disappointing. That's not a good effort from the Americans this tournament," he said.
"It's very ugly to be honest to have no one in the round of 16."
"We've got to try to rectify that next time the big tournaments roll around."
One way to rectify the visible decline of men's tennis in America is through the Davis Cup and they will get the chance to do so next month when they travel to Switzerland to take on Federer and Co. in a first-round World Group clash on clay.
But that will be a tough ask given the likely absence of Roddick, with Fish and Isner expected to head the American assault against a home team that will also include Stanislas Wawrinka.
The USA are the most successful country ever in Davis Cup history, but in recent years they haven't been close to adding to their 32 wins.
While an away victory over Switzerland won't make up for the disappointment at Melbourne Park, it might just be the boost the proud nation needs to get the confidence of their male players back.