The seeds continue to fall in the Guangzhou International Women's Open, with No.3 Akgul Amanmuradova exiting on Wednesday.
The Uzbeki suffered a straight-sets loss to India's Sania Mirza, barely raising a whimper in the 6-4 6-3 loss.
She is the fourth seed to be eliminated from the tournament at the second-round stage, joining Alberta Briant (No.7), Kai-Chen Chang (No.5), Chanelle Scheepers (No.8) and Yung-Jan Chan (No.2) in departing.
Chinese Taipei's Kai-Chen lost to Han Xinyun of China 1-6 6-2 64, while South African Scheepers was thrashed 6-1 6-0 by Zhang Shuai.
Alla Kudryavtseva had to work hard to beat Russian compatriot Ekaterina Ivanova 6-4 3-6 6-2, while Brianti lost to fellow Italian Maria Elena Camerin 6-4 3-6 6-4.
Top seed Jarmila Groth of Australia and Japan's Ayumi Morita (No.4) - both still to play their second-round matches - are the only two seeds still in the running.
Meanwhile, top seed Marion Bartoli crashed out of the Bell Challenge in Quebec on Wednesday after a shock straight-sets defeat to Rebecca Marino.
Undeterred by facing a five-time WTA tournament winner and Wimbledon finalist, qualifier Marino set up the 6-3 6-1 win with an impressive serving display that saw her land 82 percent of first serves and hit 10 aces.
Marino's shock win comes just two weeks after she won her first ever Grand Slam match at the US Open and continues the 19-year-old's rise to prominence.
The Canadian's next opponent will be Bethanie Mattek-Sands, who knocked out sixth seed Julia Goerges of Germany 6-1 6-4.
World No.71 Mattek-Sands is 30 places below Goerges in the WTA rankings, but the American eased past her opponent in just one hour and 10 minutes.
Mattek-Sands broke Georges four times throughout the encounter, while only giving away her serve once and saving break point five times.
On a day of surprises, third seed Lucie Safarova will have been relieved after she secured a straightforward victory.
The Czech world No.28 defeated 22-year-old Johanna Larsson of Sweden 6-4 6-2 in one hour and 25 minutes to book her passage into the quarter-finals.