With 32 grand slam singles titles between them, Roger Federer and Serena Williams are set to light up Rod Laver Arena on Monday night.
Williams, who has been in the wars with rolled ankles and cut lips thus far at Melbourne Park, will take on Russian 14th seed Maria Kirilenko - someone the American has a 5-0 head-to-head record against, and has dropped just one set to in their past four meetings since 2006.
The third seed - aiming to win a sixth Australian Open title - is well and truly expected to handle Kirilenko, despite the Russian having yet to drop a set through three matches so far.
Federer, though, is expected to face his toughest test yet this tournament when he meets Canadian 13th seed Milos Raonic later in the night.
Although the Swiss second seed has beaten the powerful Raonic on each of the three occasions they have met, Federer has always been under the pump to do so.
The Yugoslavia-born Raonic has taken a set off the 17-time major winner in all of their meetings - all of which were in 2012 - with their most recent clash on the grass at Halle needing to be decided by a third-set tie-breaker.
Regardless, the elegance and comfort that Federer was able to dismiss local hope Bernard Tomic in the third round on Saturday night leaves him in pole position to reach the quarter-finals in a major for the 35th time in succession.
The day session on RLA will see defending champion Victoria Azarenka continue her push for the silverware in Melbourne, as she takes on Russian Elena Vesnina.
Azarenka survived a scare against rising American talent Jamie Hampton in the third round, with the Belarusian coming from a break down in the deciding set to seal her progression.
If history is anything to go by, Azarenka should be largely untroubled by Vesnina - leading their head-to-head record 3-0, with all of those matches also coming on hard courts.
Not all of Monday's matches are expected to be one-sided, with Danish 10th seed Caroline Wozniacki preparing for the tough test of two-time major winner Russia's Svetlana Kuznetsova.
Kuznetsova knocked off the former world number one in their clash in Sydney earlier in January, winning 6-2 in the third set, while Wozniacki leads the pair's career head-to-head record 5-3.
In the final day match on centre court, it is an all-French affair with seventh seed Jo-Wilfried Tsonga taking on ninth seed Richard Gasquet.
Gasquet leads their head-to-head record 4-3, but they have not met in competition since 2009.
The Hisense Arena schedule is highlighted by the appearance of third seed Andy Murray of Great Britain, who is up against wily Frenchman Gilles Simon.
US Open champion Murray should have both the form and fitness factor in his favour against the 14th seed, after Simon was up late on Saturday night as he beat compatriot Gael Monfils 8-6 in the fifth set.
Earlier, Jeremy Chardy of France - who knocked out Juan Martin del Potro - will go up against 21st-seeded Italian Andreas Seppi, before two youngsters will battle it out for a quarter-final spot in the women's draw, namely Serbian Bojana Jovanovski and American 29th seed Sloane Stephens.