Maria Sharapova and Venus Williams renew their rivalry in the third round of the Australian Open on Friday night, while Novak Djokovic and David Ferrer face fellow seeds on day five.
Russian second seed Sharapova has yet to drop a game at Melbourne Park this year but faces her biggest test yet in the night session on Rod Laver Arena.
Williams, 32, may no longer be at her peak but the experienced seven-time grand slam champion has the game to trouble Sharapova.
Sharapova leads the head-to-head 5-4 and was the victor in Rome last year, with Williams winning the meeting prior – at Stanford in 2009.
The duo could make Spanish fourth seed Ferrer and Cypriot Marcos Baghdatis, the 28th seed, wait.
Ferrer and Baghdatis clash in the later match in what is sure to be an entertaining affair played mostly from the baseline.
Baghdatis was runner-up in Melbourne in 2006 but beating the consistently strong Ferrer is a huge ask for the 27-year-old.
In the last day match on Rod Laver Arena, Djokovic will be looking to build on his impressive display on Wednesday night when he takes on Czech 31st seed Radek Stepanek.
Djokovic labelled his win over American Ryan Harrison in the second round as his best early-round performance at a grand slam and he could be in frightening form if he gets better.
Stepanek has lost seven of his eight meetings with Djokovic and will need the Serbian, aiming for a third straight Australian Open crown, to be below his best.
Highly rated American teenager Madison Keys will fancy her chances against German fifth seed Angelique Kerber.
The pair will face off in the first match on Rod Laver before Chinese sixth seed Li Na takes on aggressive Romanian 27th seed Sorana Cirstea.
In an all-Serbian clash on Hisense Arena, 13th seed Ana Ivanovic meets Jelena Jankovic, the 22nd seed.
Ivanovic has a great record against Jankovic, winning eight of their past 11 meetings and should enter the encounter as favourite.
Polish fourth seed Agnieszka Radwanska's unbeaten start to 2013 is put to the test by Brit Heather Watson, while Spanish 22nd seed Fernando Verdasco will be challenged by big-serving South African Kevin Anderson.
Tomas Berdych, the Czech fifth seed, will be confident of advancing from his meeting with Austrian 26th seed Jurgen Melzer.
Serbian eighth seed Janko Tipsarevic meets French 32nd seed Julien Benneteau, while American Sam Querrey, the 20th seed, does battle with Swiss 15th seed Stanislas Wawrinka.
The second match on show court three is one to watch, with Spanish 10th seed Nicolas Almagro facing Pole Jerzy Janowicz.
Janowicz, seeded 24th, needed five sets to overcome Indian Somdev Devvarman in the second round, but his outburst during that clash has caught the headlines and drawn hundreds of thousands of hits on YouTube.
The fiery Almagro will go in as favourite but if Janowicz is at his best, he is capable of an upset.
Elsewhere, Japanese 16th seed Kei Nishikori meets Russian Evgeny Donskoy, German 18th seed Julia Goerges faces China's Zheng Jie and Russian Valeria Savinykh takes on Belgian Kirsten Flipkens.