Roger Federer comes up against Nikolay Davydenko in the pick of day four action at the Australian Open, where Bernard Tomic and James Duckworth continue their campaigns on Thursday.
Swiss 17-time grand slam champion Federer has quite the record against Russian Davydenko.
Of their previous 19 meetings, the 31-year-old has been victorious in 17, including the past five.
Federer crushed Frenchman Benoit Paire in his opening match and will be the hot favourite against Davydenko, who overcame Dudi Sela in the first round.
If Federer is victorious, the highly anticipated third-round clash against Australian Tomic could come to fruition.
Tomic is the third and final day match on Rod Laver Arena on what is expected to be a 39-degree day in Melbourne.
He faces Daniel Brands for the first time and he will be eager to make quick work of the German.
Tomic has said he is finding it tough to avoid thinking about a potential meeting with Federer, but will be wary of the 25-year-old Brands, who made the Wimbledon fourth round in 2010.
Duckworth will be aiming to advance to the third round of a grand slam for the first time when he takes on Slovenian Blaz Kavcic.
World number one Victoria Azarenka resumes her title defence on Rod Laver Arena when she meets Greece's Eleni Daniilidou.
She may keep an eye on the match after hers and before Tomic's, when Serena Williams does battle with Spanish teenager Garbine Muguruza.
Williams rolled her ankle in the opening round but was untested by Romanian Edina Gallovits-Hall.
As expected, the third seed cancelled her practice session on Wednesday as she continues to nurse the injury.
Williams should be largely untroubled against Muguruza, who was involved in a lengthy clash against Magdalena Rybarikova on Tuesday.
Former Wimbledon champion Petra Kvitova takes on Brit Laura Robson in a battle of the left-handers in the second night match on Rod Laver Arena.
Kvitova has been in average form to start the year but had a confidence-boosting win over Francesca Schiavone in the first round.
British third seed Andy Murray is second up on Hisense Arena and should get the job done against Portugal's Joao Sousa.
Caroline Wozniacki, the Danish 10th seed, follows against Croatian 16-year-old Donna Vekic, with Gael Monfils meeting Chinese Taipei's Lu Yen-Hsun.
French seventh seed Jo-Wilfried Tsonga takes on Japan's Go Soeda, while Argentine Juan Martin del Potro, the sixth seed, faces German Benjamin Becker in the night match on Margaret Court Arena.
Tsonga and Del Potro remain outside chances of challenging the big three and will be hopeful of continuing to go under the radar on Thursday.
Croatia's Marin Cilic should advance against American Rajeev Ram and the match-up between French ninth seed Richard Gasquet and Colombian Alejandro Falla should provide plenty of entertainment.
Other men's seeds in action include Germans Philipp Kohlschreiber and Florian Mayer, Spain's Marcel Granollers, Canadian Milos Raonic and Italian Andreas Seppi.
In the women's draw, the likes of Russian Maria Kirilenko, Americans Sloane Stephens and Varvara Lepchenko, Belgian Yanina Wickmayer, Czech Lucie Safarova and Italian Roberta Vinci are all in action.