Up to four players could make their debuts for Australia when the Wallabies meet Samoa in Sydney on Sunday.
Melbourne Rebels halfback Nick Phipps and Waratahs lock Sitaleki Timani have both been named in the starting XV, while hooker James Hanson and flanker Beau Robinson of the Reds are on the bench.
One member of the bench is yet to be named after prop Benn Robinson tweaked his knee at training on Tuesday.
The Western Force's Pek Cowan and Waratahs forward Al Baxter are in contention to replace Robinson.
Inside centre Pat McCabe will make his first Test start, with fellow Brumbies Matt Giteau and Adam Ashley-Cooper on either side of him.
Openside flanker Matt Hodgson will also start a Test for the first time after coming off the bench in his first four appearances last year.
He replaces David Pocock, who misses out due to a minor foot complaint.
Digby Ioane is the only member of the newly crowned Super Rugby champion Reds to feature in the starting line-up, with a further four Reds players to be included on the bench.
"We assessed all of the Queensland guys when they joined us on Monday night and decided this was the best course for us," Wallabies coach Robbie Deans said.
"They've had a big work load already this year. Given that our schedule is so congested, with five Test matches in seven weeks, we felt that now was realistically the only opportunity we had to give them a break."
Deans says the decision was in no way disrespectful to Samoa.
"Given the high most of those blokes had last weekend, it's my experience that it does take a little while to come down from that," he said.
"They've refocused quickly on the task at hand representing their country, which is why we've included a good group of those players in the match-day 22."
"They'll get their opportunity, they're excited, and I know they will all contribute when we call on them."
"For two of them (Beau Robinson and James Hanson), it will be their first experience representing Australia and that is a special moment no matter what the circumstance. You only play your first Test once."
Samoa have named a squad with both Super Rugby and European club experience, five of whom were previously coached by Deans at the Crusaders.
"You only have to look at Samoa's results on last year's Spring tour where they drew with Scotland and ran both Ireland and England close to see how competitive they will be," Deans said.
"They're a proud nation and their players will be excited, both by the prospect of playing on the big stage, but also the opportunity this match presents, both individually but also for Samoa as a team, on the way to the Rugby World Cup."
Sunday will be the fifth Test between Australia and Samoa and the first since 2005 in Sydney, a match that saw captain Rocky Elsom and Stephen Moore make their Test debuts.
While the Wallabies boast an excellent overall record at ANZ Stadium, having won 21 of the previous 28 Tests played at the ground, they will be looking to snap a three-match losing streak there after going down to New Zealand (2009 & 2010), and to England last year, all by a single point.
Wallabies team
Mark Gerrard, James O'Connor, Adam Ashley-Cooper, Pat McCabe, Digby Ioane, Matt Giteau, Nick Phipps, Ben McCalman, Matt Hodgson, Rocky Elsom (c), Nathan Sharpe, Sitaleki Timani, Ben Alexander, Stephen Moore, Sekope Kepu
Reserves:
16. James Hanson, 17. To be advised, 18. Dan Vickerman, 19. Scott Higginbotham, 20. Beau Robinson, 21. Will Genia. 22. Kurtley Beale