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On the opening day of the Games in Glasgow, Jack Bobridge and co put on a determined showing to see off an England team that included former Tour de France winner Wiggins alongside Ed Clancy, Steven Burke and Andy Tennant.
Bobridge, along with Luke Davison, Alex Edmondson and Glenn O'Shea secured a Games-record time of three minutes 54.851 seconds to successfully defend their title.
With four finals taking place, the gold medals continued to fly out at the Emirates Arena as Australia's Anna Meares finished first in the women's time trail courtesy of a Commonwealth record time of 33.435 seconds.
There was further disappointment for England's men's in the team sprint finals as they lost out to New Zealand.
At the Tollcross Swimming Centre, Hannah Miley retained her 400m individual medley gold with a Commonwealth record of four minutes 31.76secs before a late surge saw Ryan Cochrane edge David McKeon to take 400m freestyle gold.
Australia's Emma McKeon and Rowan Crothers clinched the 200m and 100m freestyle respectively before Ross Murdoch won the 200m breaststroke - beating favourite Michael Jamieson into second while also securing a Games record.
There was added success for Australia's women, who won the 4x100m freestyle relay for a third Games running with a world-record time of three minutes 30.98secs.
Having seen Jodie Stimpson win the women's triathlon earlier in the day, Alistair Brownlee ensured another English success in the event.
Brownlee recorded a time of one hour 48.50mins to add Commonwealth glory to his Olympic, World and European successes.
After Nick Matthew picked up a win earlier in the day, fellow Delhi Commonwealth medallists James Willstrop and Peter Barker followed suit in the squash.
World number one and defending champion Nicol David is also safely through to the next round of the women's draw after seeing off Vanessa Florens of Mauritius.
Kimberley Renicks picked up the hosts' first gold medal with a win in the under-48kg category of the judo before sister Louise followed suit in the 52kg competition.
There were further Scottish medals in the sport as James Millar clinched bronze in the men's 66kg category and Connie Ramsay finished the women's 57kg in third - the event won by England's Nekoda Davis.
As predicted, the table tennis players of Singapore and India were in fine form as their men's and women's teams made 100 per cent starts on day one.
India also enjoyed success in the weightlifting as Sanjita Khumukcham lifted 173kg to claim the women's 48kg competition with compatriot Sukhen Dey taking first in the men's 56kg group.
Canada won the rhythmic gymnastics ahead of Wales - who had led the competition for much of its duration - with Malaysia taking the bronze medal.