Simon Katich threw his wicket away by playing a reckless swipe to the part-time spin of Hodge only to find his stumps rattled for just two before Hughes' out-of-sorts knock finally came to an end.
The former Test opener - who managed just 44 off 91 balls - gave McGain his third wicket after Hussey took a magnificent running catch going the same way as the ball at mid-on after Hughes finally attempted to pick up his and the team's run rate.
New South Wales then continued to lose wickets at regular intervals despite the Vics being a bowler down after James Pattinson limped off with a foot injury which is almost certain to keep him out of Friday's Sheffield Shield clash between these two teams.
New South Wales innings
Jaques c sub (Blizzard) b McGain 60 (65)
Hughes c Hussey b McGain 44 (91)
S Smith c Rogers b McGain 8 (17)
Katich b Hodge 2 (5)
Henriques c McDonald b Hastings 13 (30)
Thornley c Quiney b McDonald 32 (31)
Warner c McDonald b Nannes 16 (19)
D Smith b Nannes 14 (13)
Starc c Hastings b Nannes 9 (15)
Bracken c Rogers b Hazelwood 5 (7)
Hazelwood not out 5 (5)
Extras: 16 (5b, 2lb, 1nb, 8w)
Total: 224 (49.3 overs)
FOW: 1-90, 2-111, 3-114, 4-124, 5-143, 6-173, 7-198, 8-213, 9-215, 10-224
Bowling
Nannes 10 - 1 - 40 - 3
J Pattinson 3 - 0 - 14 - 0
Hastings 7.3 - 0 - 48 - 2 (1nb, 8w)
McDonald 10 - 0 - 47 - 1
McGain 10 - 0 - 37 - 3
Hodge 9 - 0 - 31 - 1
Victoria innings
Rogers c Hughes b Hazelwood 9 (17)
Finch c S Smith b Bracken 44 (53)
Hodge c D Smith b Starc 5 (13)
Hussey c Jaques b Bracken 45 (40)
McDonald not out 42 (62)
Wade c Henriques b Thornley 50 (64)
Quiney not out 4 (4)
Extras: 17 (3lb, 9w, 5nb)
Total: 216 (five wickets, 42.4 overs)
FOW: 1-20, 2-32, 3-110, 4-110, 5-211
Bowling
Bracken 9 - 1 - 34 - 2 (4w)
Hazelwood 9 - 1 - 44 - 1
Starc 8.4 - 0 - 62 - 1 (5nb)
S Smith 9 - 1 - 36 - 0
Thornley 6 - 0 - 31 - 1 (5w)
Henriques 1 - 0 - 6 - 0
VICTORIA WINS BY FIVE WICKETS
Points: Victoria 4, New South Wales 0