Top seed Jelena Jankovic made it safely through to the second round of the Banka Koper Slovenia Open in Portoroz with a 6-3 6-3 victory over Serbian youngster Bojana Jovanovski.
But second seed Petra Kvitova was brought back to earth with a bump in her first match since her storming run to the Wimbledon semi-finals. The young Czech was beaten 7-5 6-2 by Switzerland's Stefanie Voegele.
There were no such problems for her fellow high seeds, with third seed Anastasia Pavlyuchenkova easing past Alberta Brianti 7-5 6-1, and fourth seed and last year's beaten finalist Sara Errani downing qualifier Anna Tatishvili 7-6 (7-1) 6-4.
Johanna Larsson was a surprise 7-6 (7-1) 6-2 winner over eighth seed and fellow Swede Sofia Arvidsson, but seventh seed Polona Hercog progressed with a 6-3 6-3 win over qualifier Elena Bovina.
Australia's Anastasia Rodionova won the first set before losing to Italian Maria Elena Camerin 4-6 6-2 6-4.
Meanwhile, top seed and defending champion Andrea Petkovic took just 73 minutes to polish off Czech opponent Iveta Benesova 6-4 6-0 and get the defence of her Nurnberger Gasteinladies title in Bad Gastein off to a winning start.
Petkovic made her big breakthrough at the same event last season and has improved steadily since, making her far too strong for Benesova, whose weak serve let her down.
Second seed Timea Bacsinszky also breezed through with a 6-1 6-2 win over Germany's Anna-Lena Groenefeld, while seventh seed Tathiana Garbin needed three sets to beat Frenchwoman Pauline Parmentier 3-6 6-3 6-1.
But there were some big casualties on Tuesday with third seed Anabel Medina Garrigues losing 6-4 7-5 to Austrian Yvonne Meusburger and fourth seed Klara Zakopalova falling to German Julia Goerges 6-2 5-7 6-1, while fifth seed Sybille Bammer also made an early exit after she lost to Russian Anastasia Pivovarova 6-7 (10-12) 3-6.
In a Czech family affair, sixth seed and last week's Prague finalist Barbora Zahlavova Strycova was beaten 7-5 6-3 by Sandra Zahlavova - who is the cousin of Strycova's husband.