The Team Penske man led for 138 of 305 laps at the New Hampshire Motor Speedway in Loudon, as he claimed his third race win of the season - and made it 10 top-10 finishes in 19 starts.
Keselowski (634 points) is behind only Hendrick Motorsports pair Jeff Gordon (670) and Dale Earnhardt Jr (658) in the championship standings.
Getting on the podium in New Hampshire were Joe Gibbs Racing's Kyle Busch and Chip Ganassi Racing rookie Kyle Larson, with Busch having led for 62 laps before earning a runner-up finish.
It was Larson's second podium finish in his 22nd career NASCAR race.
Keselowski said he was keeping his head out of the clouds, as the 2012 Sprint Cup Series winner climbed the championship standings.
"I'm not thinking of anything else right now (other) than how thankful I am to have a team and a car that is clicking well," Keselowski said.
"It's every driver's dream.
"I think, in a lot of ways, we're stronger than (2012). I don't think we've had this much speed before. I feel like I'm in a really strong rhythm right now.
"I think some of last year's struggles put me in a spot to work harder and become a better race car driver.
"I think we're combining all those things and we're seeing the fruits of that labour - with more to come."
Outside the podium placings, Joe Gibbs Racing's Matt Kenseth, Richard Childress Racing's Ryan Newman and Michael Waltrip Racing's Clint Bowyer were next in.
Rounding out the top 10 were Tony Stewart (Stewart-Haas Racing), Denny Hamlin (Joe Gibbs Racing), Ricky Stenhouse Jr (Roush Fenway Racing) and Dale Earnhardt Jr (Hendrick Motorsports).