Wests Tigers centres Blake Ayshford and Chris Lawrence have been ruled out for up to six weeks with injuries suffered in Saturday's 20-10 loss to Brisbane at Campbelltown Stadium.
Ayshford has a syndesmosis injury in his right ankle while Lawrence strained his hamstring on a disastrous night for the Tigers, with half-back Tim Moltzen suffering a season-ending knee injury.
The Tigers are missing 10 players through injury in total, including halves Benji Marshall (toe), Braith Anasta (groin) and prop Keith Galloway (pec).
Lote Tuqiri (arm), Matt Bell (hand), James Gavet (knee) and David Nofoaluma (knee) are the other members of the Tigers' bulging casualty ward.
There is one positive for the joint-venture club, with Fijian winger Marika Koroibete set to return for the must-win clash against the Bulldogs on Friday night at ANZ Stadium.
Meanwhile, the Bulldogs are expected to welcome back suspended prop James Graham and his front-row partner Sam Kasiano (leg) for the Round 8 clash against the Tigers.