Wests Tigers prop Aaron Woods, Penrith Panthers winger Josh Mansour, South Sydney Rabbitohs flyer Dylan Walker and Sydney Roosters giant Daniel Tupou are the new faces for the Suncorp Stadium clash.
Aidan Guerra will earn his first start off the bench.
The Kiwis have handed debuts to two players - the North Queensland Cowboys' Jason Taumalolo and teenage wing sensation Dallin Watene-Zelezniak.
Kangaroos squad: Greg Inglis, Josh Mansour, Michael Jennings, Dylan Walker, Daniel Tupou, Daly Cherry-Evans, Cooper Cronk, Aaron Woods, Cameron Smith (c), Sam Thaiday, Beau Scott, Ryan Hoffman, Greg Bird, Robbie Farah, Aidan Guerra, Josh Papalii, Corey Parker, Boyd Cordner, David Klemmer, Sione Mata'utia.