Luke Hyam put the visitors ahead after 19 minutes and former Wigan man Conor Sammon's second-half strike sealed the points, despite Martyn Waghorn's late goal setting up a tense finish.
The result lifts Mick McCarthy's side up to seventh - just three points short of second spot - while Wigan, who qualified for the play-offs last season, are left languishing in 17th.
Hyam started and finished the move that broke the deadlock, the defender scoring his first goal of the season with a close-range finish from Tyrone Mings' cross.
Uwe Rosler's men were proving wayward with their finishing, a fact underlined by Andy Delort's off-target header from a threatening delivery.
Ipswich took control of proceedings when Sammon, on loan from Derby County, opened his account for the club in the 63rd minute, netting against his former employers.
David McGoldrick picked out the Irish forward and he managed to stab the ball home at the second attempt.
Waghorn reduced the deficit when he helped James McClean's effort on its way into the net, and substitute Oriol Riera struck the post late on.
However, there was no way back for the hosts as Ipswich went some way to redressing the balance after losing twice to Wigan last term.