Serie A rivals Fiorentina and Roma will lock horns in a mouth-watering UEFA Europa League round-of-16 tie next month.
Fiorentina coach Vincenzo Montella spent 10 years at Roma during his playing days and also had a spell as caretaker coach at Stadio Olimpico, but there will be no room for sentiment when his side attempt to dump the Eternal City club out of Europe.
Montella's side, who knocked out Tottenham in the round of 32, will be at home for the first leg on March 12 and travel to Rome a week later.
Fiorentina knocked Roma out of the Coppa Italia earlier this month, so Rudi Garcia's side have an opportunity to exact revenge.
Roma beat Feyenoord among a backdrop of crowd disturbances on Wednesday, winning 2-1 on the night and 3-2 on aggregate.
There will also be an all-Spanish tie in last 16, with holders Sevilla taking on Villarreal.
Sevilla were crowned champions when they beat Benfica last season and Unai Emery's side knocked out Borussia Monchengladbach to keep their hopes of lifting the trophy again alive.
Villarreal, conquerors of Salzburg in the round of 32, will be at home in the first leg.
A clash between Bundesliga high-flyers Wolfsburg and in-form Inter was another standout tie when the draw was made in Nyon on Friday.
Inter beat 10-man Celtic 1-0 - and 3-2 on aggregate - courtesy of a late Fredy Guarin strike at San Siro on Thursday and the Serie A outfit have won four of their last five matches.
Rafael Benitez is aiming to win this tournament for the second time in the space of three years and his Napoli side will take on Dynamo Moscow.
Besiktas beat Liverpool on penalties in the round of 32 and the Istanbul club will fancy their chances of seeing off Club Brugge, while Everton - the only English club remaining in the competition will face Dynamo Kiev.
Ajax travel to Dnipro in the first leg of their tie, while Zenit will be at home in the first leg of their tie with Torino.
Draw in full:
Everton v Dynamo Kiev
Dnipro v Ajax
Zenit v Torino
Wolfsburg v Inter
Villarreal v Sevilla
Napoli v Dinamo Moscow
Club Brugge v Besiktas
Fiorentina v Roma