The Americans have shown why they are a class above so far in Group C, chalking up 310 points in three matches - most recently downing New Zealand 98-71 on Tuesday.
Assured of their spot in the last 16, Mike Krzyzewski's men have two games to tinker with their set-up before the knockout stages - starting with their clash against the Dominican Republic on Wednesday.
Anthony Davis is tied eighth for most points at the tournament so far - level with Croatia's Bojan Bogdanovic on 57 - and the New Orleans Pelicans forward said the Kiwis were a good test for the star-powered Americans.
"We definitely scored the ball, definitely got after it," Davis said, after their win in Bilbao.
"It was a good test for us. We like playing against good competition, and they were definitely one of those opponents."
Also in Group C, Ukraine can virtually end New Zealand's hopes of progressing when the two nations meet.
The Ukrainians sit second behind Team USA with a 2-1 record, having downed Turkey 64-58 in a low-scoring affair.
Eugene Jeter (50 points) has been Ukraine's top scorer at the tournament.
Turkey, fourth in the group, face Finland in the other Group C contest, with the winner set to hold their own knockout-stage fate in their hands heading into the final group matches.
In Gran Canaria, Group D leaders Slovenia will look to preserve their unbeaten status when they take on Angola.
Goran Dragic (61 points at 70.6 per cent efficiency) has been the star for Jure Zdovc's charges, who can also afford to experiment having sewed up their last-16 place.
Australia can ensure themselves of progression with a win over Mexico, while Lithuania will likewise move on should they dispatch of South Korea.
Hosts Spain have been dominant throughout in Group A, and they will look to preserve their form when they take on France in Granada.
The match will pit the top two nations in the group against one another, although the four sides to progress have all but been set with each of Iran and Egypt winless.
The two struggling nations will face off to try and break their duck, while third-place Serbia will take on Brazil in fourth with the winner assured of advancing.
In Seville, Group B pace-setters Greece are three-from-three but have a tough challenge to stay unbeaten against Croatia.
Earlier, the winless Philippines will vie to remain off bottom spot against fellow strugglers Puerto Rico before Senegal and Argentina go head-to-head.