The Spaniards made it seven wins from as many games thanks to a lopsided third quarter and Jonas Maciulis' dominant display in Madrid.
Real outscored UCAM Murcia 28-8 in the penultimate period to set up the team's biggest winning margin of the season so far.
Maciulis had a game-high 20 points and seven rebounds in the Spanish capital.
Real team-mates Felipe Reyes (12 points), Jaycee Carroll (11 points), Ioannis Bourousis (11 points) and Sergio Llull (10 points) made contributions.
Murcia, who slipped outside of the top eight with a 4-3 win-loss record, were led by Nemanja Radovic and his 16 points.
Raulzinho Neto (13 points) was the only other Murcia player to make it into double figures.
FC Barcelona and Unicaja both improved to 6-1 following their respective wins.
Barcelona made it back-to-back wins with a 76-57 victory over Valencia.
Maciej Lampe inspired the triumph, posting a game-best 20 points in less than 17 minutes on court.
Unicaja bounced back from their loss to FIATC Joventut by accounting for Iberostar Tenerife 84-68.
Mindaugas Kuzminskas (20 points), Caleb Green (17 rebounds) and Ryan Toolson (15 points) all starred for the Unicaja.
In other results, Bilbao dropped to fourth in the standings after slumping to an 82-71 loss to CAI Zaragoza.
Sevilla won for a second consecutive week, downing Tuenti Movil Estudiantes 82-65.
Laboral Kutxa were 79-62 winners over Gipuzkoa, while MoraBanc Andorra edged Joventut 84-81.
Kyle Kuric had 21 points as Herbalife Gran Canaria beat La Bruixa d'Or 81-73 and Montakit Fuenlabrada lost 75-63 to Rio Natura Monbus.