Harden scored 41 points, pulled down 10 rebounds, had six assists and six steals to lead the Rockets past the Portland Trail Blazers 118-113 after overtime at the Toyota Center.
He became just the second player since 1985-86 to manage those stats, joining illustrious company in Michael Jordan.
Jeremy Lin gave him plenty of support with 26 points as the Rockets improved to 44-19, sitting second in the Southwest Division.
The Trail Blazers were unable to stop the Rockets winning their fifth straight game despite several good performances.
LaMarcus Aldridge (28 points, 12 rebounds), Wesley Matthews (26 points) and Damian Lillard (21 points) were their leading scorers.
The Miami Heat slumped to their third straight loss, beaten 95-88 by the Chicago Bulls after overtime.
DJ Augustin (22 points) and Joakim Noah (20 points, 12 rebounds) helped the Bulls sink the Southeast Division leaders.
The Central Division-leading Indiana Pacers slipped to their fourth straight loss – a 105-94 defeat at the hands of the Dallas Mavericks.
Jodie Meeks scored a career-high 42 points to lead the Los Angeles Lakers to an upset 114-110 win over the Oklahoma City Thunder.
The New Orleans Pelicans needed overtime to edge past the Denver Nuggets 111-107 and the Boston Celtics claimed a 118-111 victory over the Detroit Pistons.
The Brooklyn Nets easily beat the Sacramento Kings 104-89 and the Toronto Raptors beat the Minnesota Timberwolves 111-104.
The Golden State Warriors won their fourth straight with a 113-107 victory over the Phoenix Suns.
Miami Heat, Indiana Pacers humbled, James Harden fires Houston Rockets
