Danny Santana (four runs batted in), Joe Mauer, Oswaldo Arcia and Trevor Plouffe (all with three) had big hands in helping the Twins to a 20-6 victory over the Tigers.
It was the most runs Minnesota had put up since a 20-1 win over the Chicago White Sox in May 2009.
A six-run second inning and a nine-run sixth were the catalysts for Minnesota's big victory, which saw them out-hit Detroit 20-15.
The Tigers have dropped 2.5 games behind the Kansas City Royals in the American League's (AL) Central standings.
Kansas City beat the Texas Rangers 6-3 on the back of a strong performance from starting pitcher Yordano Ventura.
In the AL West, the Oakland Athletics pulled within a game of division leaders the Los Angeles Angels courtesy of a 5-3 win over their rivals.
Sonny Gray earned his 13th win this season, the Oakland pitcher producing over eight innings of work for the concession of just three runs.
The Seattle Mariners dealt the Boston Red Sox their sixth straight loss in dramatic fashion, scoring all of their runs atop the ninth inning to steal a 5-3 win.
Leading the AL's East division, the Baltimore Orioles suffered a 4-1 loss to the Chicago Cubs.
The Orioles maintain an eight-game lead, despite closest rivals the New York Yankees winning against the White Sox 4-3.
Nine games off the pace, the Toronto Blue Jays were thrashed 8-0 by the Tampa Bay Rays.
A three-run homer from Jon Singleton in the ninth inning helped the Houston Astros cap a 5-1 victory over the Cleveland Indians.
In the National League (NL), East division leaders the Washington Nationals saw their winning streak halted at 10 matches - as the San Francisco Giants sauntered to a 10-3 win.
The Giants sit 3.5 games off the pace in the NL West standings, after the Los Angeles Dodgers made it three wins in a row with a 6-2 result over the New York Mets.
Washington remain six games clear of the Atlanta Braves, despite the latter's 3-1 extra-innings win over the Cincinnati Reds.
The Miami Marlins put up six runs in the ninth inning as they brushed aside the Colorado Rockies 13-5.
The St Louis Cardinals suffered a 5-4 loss to the Philadelphia Phillies that leaves them 1.5 games behind the Milwaukee Brewers in the NL Central division.
Milwaukee suffered their second straight loss, an 8-3 humbling at the hands of the Pittsburgh Pirates.
The Arizona Diamondbacks were 5-1 winners over the San Diego Padres.