Mike Carp's line drive in the bottom of the ninth inning saw the Boston Red Sox overcome the Baltimore Orioles 6-5.
The Orioles had led 5-0 in the middle of the sixth before Boston began their comeback.
Jonny Gomes' three-run homer in the sixth reduced the deficit to two before the Red Sox were level in the seventh.
A wild throw from David Lough from Carp's line drive in the ninth saw Dustin Pedroia score to complete the comeback win.
The Chicago White Sox's offense was at their best to lead their side to a thumping 16-2 win over the Texas Rangers.
A seven-run ninth inning sealed the win as the White Sox, who had scored just four runs in three games coming into the clash, crushed the Rangers.
Marcus Semien had four RBIs, while Conor Gillaspie and Jose Abreu had three each.
Curtis Granderson's walk-off sacrifice fly in the 14th inning helped the New York Mets finally get past the Atlanta Braves 4-3.
The Milwaukee Brewers also needed 14 innings to claim a win, with Khris Davis delivering the solo homer in a 3-2 victory against the Pittsburgh Pirates.
David Murphy's three-run double saw the Cleveland Indians to a 6-4 win over the Toronto Blue Jays.
Trevor Plouffe had two RBIs in the Minnesota Twins' comfortable 8-3 victory against the Kansas City Royals.
Yasiel Puig produced a three-run homer in the sixth to see the Los Angeles Dodgers beat the Arizona Diamondbacks 4-1.
The Washington Nationals split their four-game series against the St Louis Cardinals after a 3-2 win and the New York Yankees' four-run 12th inning saw them past the Tampa Bay Rays 5-1.
The Detroit Tigers edged past the Los Angeles Angels 2-1 and the Miami Marlins got the better of the Seattle Mariners 3-2.
The Chicago Cubs were no match for the Cincinnati Reds as they suffered an 8-2 loss and the Oakland Athletics completed a sweep of the Houston Astros with a 4-1 win.
The Philadelphia Phillies battled past the Colorado Rockies 10-9 and the San Francisco Giants scored four times in the first two innings to beat the San Diego Padres 4-3.