A 3-2 win over the Minnesota Twins grew the Orioles' lead in the American League's East division standings, with the New York Yankees' shutout loss to the Toronto Blue Jays seeing them slip further back.
The Blue Jays were 2-0 winners over the Yankees, to be 10.5 games off the division lead - and six games behind the wildcard spots.
In front of their home fans, Baltimore were powered to victory by a star performance from Jimmy Paredes, who struck a homer and a double to see off the Twins.
In Toronto, a two-run homer to Jose Bautista in the first inning was all the Blue Jays needed, as Drew Hutchison pitched seven innings of one-hit baseball.
The Tampa Bay Rays were 7-0 winners over the Boston Red Sox, who had just one hit for the entirety as Jake Odorizzi pitched his 10th win of the season.
The AL Central division could not be closer, with the Detroit Tigers and Kansas City Royals level with 74-61 records.
Detroit split a double-header with the Chicago White Sox, losing game one 6-3 but bouncing back with an 8-4 win.
The Royals, meanwhile, were trumped 3-2 by the Cleveland Indians after 11 innings - the victors just three-and-a-half games behind the leading duo.
The Los Angeles Angels continued on their merry way, chalking up a fifth straight win - a 2-0 shutout of AL West rivals the Oakland Athletics - to sit four games clear in the division.
A third straight loss left the Seattle Mariners nine-and-a-half games behind the Angels, as the Mariners were trumped 3-1 by the Washington Nationals.
The Houston Astros' 2-0 win over the Texas Rangers officially ended the latter's mathematical chances of winning the division.
Washington are seven games clear in the National League's East division, after closest rivals the Atlanta Braves were humbled 4-0 by the Miami Marlins.
The Marlins are five-and-a-half games outside the wildcard places.
The Philadelphia Phillies were 7-2 winners over the New York Mets.
NL Central pace-setters the Milwaukee Brewers continued their slump, losing 3-1 to the San Francisco Giants.
The Brewers are just a game clear of the St Louis Cardinals, who crushed the Chicago Cubs 13-2, while the Pittsburgh Pirates are two games off the lead after a 3-2 win over the Cincinnati Reds.
NL West leaders the Los Angeles Dodgers fell to consecutive losses, the San Diego Padres beating them 2-1, to allow the in-form Giants back within two-and-a-half games.
The Padres' fourth straight win leaves them seven-and-a-half games behind the wildcard spots.
The Colorado Rockies enjoyed a 2-0 shutout win over rivals the Arizona Diamondbacks.