Veteran right-hander Colon took a perfect game into the seventh inning of the Mets' 3-2 win over the Seattle Mariners
He retired 20 straight batters before Robinson Cano got on base, but the Mariners' two runs in the eighth were never going to be enough.
Another pitcher, Jorge De La Rosa, produced 7.1 brilliant innings to see the Rockies beat the Washington Nationals 6-4.
De La Rosa struck out 11 and the Rockies' three-run first inning set up the win, ending their seven-match losing streak.
The New York Yankees claimed a 2-1 win over the Texas Rangers after just five innings, with rain having made the field unplayable.
The Toronto Blue Jays rallied from behind twice on their way to a 6-4 victory against the Boston Red Sox at the Rogers Centre.
An error in the top of the ninth inning led to the Kansas City Royals overcoming the Chicago White Sox 2-1.
Hunter Pence's three-run double in the top of the ninth saw the San Francisco Giants battle to a 3-1 win over the Philadelphia Phillies.
Freddie Freeman crushed a three-run homer in the second as the Atlanta Braves eased past the Miami Marlins 6-1.
The Milwaukee Brewers completed a sweep of the Cincinnati Reds with a 5-1 win and the Minnesota Twins edged the Cleveland Indians 3-1.
The Detroit Tigers brushed past the Arizona Diamondbacks 11-5 and the Pittsburgh Pirates beat the Los Angeles Dodgers 6-1.
The Los Angeles Angels edged the Baltimore Orioles 3-2 and the Oakland Athletics set up their 9-7 win over the Houston Astros with a five-run second.
The Tampa Bay Rays were 3-0 winners over the St Louis Cardinals and the San Diego Padres completed an 8-3 victory against the Chicago Cubs.