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Hayne fumbled the ball during a punt return against the Baltimore Ravens in week six and has slowly been having his game time reduced over the past couple of games.
Jarryd Hayne INACTIVE for first time in #49ers career
— Cam Inman (@CamInman) October 22, 2015
The 49ers match against the Seahawks kicks off at 11:30am (AEST) on Friday.