The Ducks had twice as many shots as opponents the Columbus Blue Jackets to post a 4-1 win at the Honda Center.
Corey Perry and Sami Vatanen's powerplay goals had the Ducks two goals up inside nine minutes, although the Blue Jackets capitalised on a powerplay of their own when Scott Harnell scored to reduce the deficit at the first break.
Devante Smith-Pelly reinstated Anaheim's lead midway through the second period, before Ryan Getzlaf's empty-netter late in the third period sealed a comprehensive win for Bruce Boudreau's men.
The Ducks have not tasted defeat since a season-opening loss to the Philadelphia Flyers and have conceded just three goals in their past four outings.
The Tampa Bay Lightning sit in second in the Eastern Conference's Atlantic standings after their fifth win in eight matches saw them overcome the Winnipeg Jets 4-2.
The Colorado Avalanche broke through for just their second win of the campaign, routing the Vancouver Canucks 7-3.
Despite conceding inside the game's opening 10 seconds and trailing at the first break, the Avalanche piled on six goals in a 34-minute period to storm to victory.
The Edmonton Oilers had to scrape their way past the Carolina Hurricanes 6-3, after thrice losing a lead.
Jay Harrison's goal in the eighth minute of the third period was the Hurricanes' third equaliser of the match but Leon Draisaitl, Ryan Nugent-Hopkins and Matt Hendricks goals wrapped up a comfortable Oilers victory in the end.
The Dallas Stars were clinical at the death in their 3-2 shootout triumph over the New Jersey Devils.
Jason Spezza and Jamie Benn were both on target in the shootout for Dallas' second straight win, which took them second in the West's Central standings behind the Nashville Predators.