Former anti-doping chief Richard Ings told Fairfax newspapers at the weekend infraction notices against Essendon players were about to be enforced.
But speaking a club sponsorship announcement, Little said Ings' theory was unsubstantiated.
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"In discussions we've had with the various authorities that are at the centre of this issue, they've given me a level of confidence that it is unlikely," he said.
"People who continually bring it up and fan the flames, that's clearly driven by other motives.
"I don't think they understand nor do they really care too much about us.
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"There could be new information. But the reference in the press at the weekend that there are infraction notices on the way is simply incorrect.
"The AFL know nothing about that. We don't know anything about that and I'm not concerned about that.
"The government, ASADA, the AFL are probably the key bodies ... There are a number of vested interests in this and we try to stay close to all of them."
Meanwhile stand-in coach Mark Thompson said the supplements scandal had not been a major talking point so far at preseason training.
"You can't spend too much time thinking about it," he said.
"That (doping scandal) has happened. We're looking at the present. We're looking at the future."
The Bombers have now left their left traditional base at Windy Hill permanently, with all training facilities now at the new Tullamarine headquarters.
"This place is only going to help the football club," Thompson said.
"We won't have that many closed sessions. We're going to try to invite our members in and just try to restore a bit of faith in us and just give them a better experience than what they've had in the past ... make them proud of our club."